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A year ago, the 49ers looked to have one of the NFL's most dynamic one-two punches at receiver with Aiyuk (knee) and Samuel. They'll open 2025 with neither. Samuel was traded to the Commanders during the offseason, and Aiyuk will almost certainly begin the year on the Physically Unable to Perform (PUP) list after sustaining a torn ACL and MCL in Week 7 last season. The rehab is reportedly going well, but there's no definitive timeline for a return.
Further clouding Aiyuk's outlook for this season is his lack of production prior to the knee injury. In six games, the freshly minted $30 million a year wideout had collected 23 receptions, 351 yards, and 0 touchdowns with much of that coming in Week 5 (8-147-0) -- he failed to reach the 50-yard plateau in any of his other games. With so much uncertainty, Aiyuk is only worth rolling the dice on in the final rounds, and even then, only if you can stash him in an IR slot. Otherwise, you're better served keeping Aiyuk on a watch list and considering adding him when he appears ready to suit up.
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Brandon Aiyuk likely to return in early October Shanahan: WR is "on track" to return around Week 6 By: Doug Orth | Tue Aug 12, 10:10 pm

| | Kyle Shanahan said all of the 49ers' ACL guys - including Brandon Aiyuk - are on track to be back around Week 6, he said. He said there's a range of weeks that Aiyuk could actually be back in a game, but that's the rough estimate at this point. (The Athletic - Matt Barrows)
FFToday's Take: This suggests that Jauan Jennings and Ricky Pearsall will each have a nice runway for the first half of the season if they can get healthy in time for Week 1. Given how uncertain Aiyuk's return date sounds, there is a world Jennings and Pearsall can operate as clear starters for at least half of the season. Outside of the receivers, Aiyuk's absence figures to boost the floors of Christian McCaffrey and George Kittle.

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